I've noticed two small issues using QLC+ 4.10.2 (although these are not unique to this version, to the best of my knowledge).
1) Try as I might, I can't seem to get a MIDI controller to control fixture groups (as in I setup the control channel where I setup the fixture group). I've never used this function before, so I'm not 100% sure how it's supposed to work, but it doesn't seem to be doing anything and that can't be right.
2) I wish QLC+ would directly support my NI Maschine controller in MIDI mode. Right now, QLC+ can see the MIDI input and output for the Maschine controller (that would be the actual MIDI plugs on the unit), but not the MIDI connection over the USB (where the MIDI for the actual commands gets sent). As a workaround, I'm using MIDI patchbay to route the MIDI from the Maschine to an IAC bus and then into QLC+ which, while it works, is a little kludgy. I assume this has something to do with the way that the Maschine virtual MIDI port is seen by QLC+ which may or may not be something minor.
3) Blackout. This one is a bit more impactful. From all indications, Blackout is supposed to be able to blackout only intensity channels (if selected appropriately). However, that does not seem to be functioning correctly for me. Instead, Blackout affects all channels regardless of setting.